![]() ![]() This expression pattern perfectly mimicked endogenous TSPO expression. ![]() Promoter fragments extending 2.7-kb and 805-bp upstream of the transcription start site were able to direct enhanced green fluorescent protein expression to Leydig cells of the testis, theca cells of the ovary, and cells of the adrenal cortex in transgenic animals. In this study, we characterized the regulatory elements present in the region of the TPSO promoter extending from 515 to 805-bp upstream of the transcription start site, an area previously identified as being important for transcription. TSPO is highly expressed in secretory and glandular tissues, especially in steroidogenic cells, and its expression is altered in certain pathological conditions such as cancer and neurological diseases. The translocator protein (18kDa TSPO), previously known as peripheral-type benzodiazepine receptor, is a high affinity cholesterol- and drug-binding mitochondrial protein involved in various cell functions including steroidogenesis, apoptosis, and proliferation.
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